2007 Steelers 22 vs Jaguars 29
Normally, snow, wind and cold would favor the Steelers. But the physical Jaguars beat the Steelers at their own game as Fred Taylor plows his way for 147 yds on 25 carries, including the game-winning TD with under 2 minutes left.
The Steelers fall behind 22-7 before Ben Roethlisberger mounts a characteristic 4th quarter comeback to tie the game at 22 with TD passes to Hines Ward and Nate Washington (with a surprising Santonio Holmes to Cedrick Wilson pass for a 2-point conversion). But the Steelers can't stop the one-two punch of Taylor and MJD as the Jaguars drive 73 yds -- all but 20 of it on the ground -- to seal a Jaguar win.